Thuoc giam dau ha sot khang viem khong steroid

– Paracetamol is metabolized primarily in the liver and a small part in the kidneys, forming derivatives conjugated glucuronic and sulfonic. The clearance of paracetamol in the urine as combined glucuronic is about 50 to 80%, as conjugate sulfonic about 20 to 30%, unchanged <5%. A fraction (<4%) is metabolized by cytochrome P450 into N-acetyl parabenzoquinonimin metabolite, which is then detoxified quickly by the liver’s glutathione. However, if high dose of paracetamol is taken, these metabolites are formed at the high  enough level to deplete hepatic glutathione, in which case, its reaction with sulfhydryl of liver protein increase and so can lead to liver necrosis.

Thuoc giam dau ha sot khang viem khong steroid

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