A study released by the National Academies of Sciences, Engineering, and Medicine cited significant evidence for a statistical link between mothers who smoke marijuana during pregnancy and lower birth weights of their babies.  Cannabis consumption in pregnancy is associated with restrictions in growth of the fetus, miscarriage, and cognitive deficits in offspring.  Although the majority of research has concentrated on the adverse effects of alcohol, there is now evidence that prenatal exposure to cannabis has serious effects on the developing brain and is associated with "deficits in language, attention, areas of cognitive performance, and delinquent behavior in adolescence".  A report prepared for the Australian National Council on Drugs concluded cannabis and other cannabinoids are contraindicated in pregnancy as it may interact with the endocannabinoid system . 
Most patients with back pain will not benefit from surgery. However, if anatomic abnormalities consistent with the distribution of pain are identified, surgery can be considered in persons who have experienced significant functional disabilities and in those with unremitting pain, especially pain lasting longer than 12 months despite multiple nonsurgical treatments. Good evidence supports the use of spinal fusion for treating back pain caused by fractures, infections, progressive deformity, or instability with spondylolisthesis. 7 Spinal decompression, nerve root decompression, and spinal fusion have been extensively evaluated for the treatment of degenerative disorders of the spine, mostly with short-term outcomes, yielding conflicting results and questionable patient benefit. 39 Disk arthroplasty (replacing the original intervertebral disk with an artificial one) appears to be as effective as lumbar fusion for short-term relief of chronic low back pain, but there is no evidence of long-term relief, and concerns exist regarding the durability of the artificial disks. Intradiscal electrothermal therapy is a technique that applies heat to a damaged disk through a catheter, causing collagen contraction for structural support and ablating nearby pain-sensing nerves for pain reduction. It has been shown to provide modest pain relief, but little functional improvement. 40
Exacerbation or initial presentation of a number of autoimmune and inflammatory disorders have been reported (See “ WARNINGS ” section, “ PRECAUTIONS ” section, “ DRUG INTERACTIONS ” section). Persistent but nonprogressive vitiligo has been observed in malignant melanoma patients treated with interleukin-2. Synergistic, additive and novel toxicities have been reported with Proleukin used in combination with other drugs. Novel toxicities include delayed adverse reactions to iodinated contrast media and hypersensitivity reactions to antineoplastic agents (See “ PRECAUTIONS ” section, “ DRUG INTERACTIONS ” section).