During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.
Inform your physician of all the medications you take (prescription and over the counter) and other medical conditions you have before taking a Medrol Dose Pack. If you are scheduled for surgery, the medical staff must be aware that you are on a Medrol Dose Pack. It never should be taken if you are allergic to methylprednisolone or have a fungal infection. Since steroids can weaken the immune system, avoid people who have colds and the flu. Contact your physician if you become exposed to the measles or chicken pox, as these illnesses can become serious when a person is on steroid medication.