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There are other types of thermogenic supplements that do not fit into the above categories. Pyruvate is one of these. This form of pyruvic acid is synthesized by the body and found in food. It helps to produce ATP, which is an essential biological energy source. In studies, pyruvate has been shown to significantly aid in fat loss when combined with a healthy diet and exercise. Studies in animals have suggested that pyruvate may increase metabolism while reducing insulin resistance. Other research indicates that pyruvate might also enhance endurance during exercise, which would also promote fat loss.