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The German Democratic Republic ceased to exist in 1990, joining the Federal Republic of Germany in the process of German reunification . Accordingly, the "NOC of the GDR" joined the "NOC of Germany" on 17 November 1990. German athletes competed at the Olympic Games as a single team again from 1992 onwards. Athletes from the Eastern part of Germany contributed disproportionately to the medals won by Germany, particularly in the first decade after reunification. This is thought to indicate that doping was not the only reason East Germany was so successful (and more successful than West Germany in particular) in the Olympics, with professional training conditions also being significant. The practice of doping was implemented by a separate state, a former rival who was far less successful. The medal tally of reunited Germany after 1990 was more comparable to that of East Germany before 1990 than of West Germany before 1990. For example, of the twenty nine medals Germany won in the 2006 Winter Olympics East German born (containing one-fifth of the population of Germany) athletes won fourteen (six gold). West German athletes won only nine medals (three gold), with six medals won in mixed teams. In recent years, some centres of German top-class sport have relocated to the West, for example winter sports to Bavaria. However, the East is still performing better than the West. Trainers from East Germany (. Uwe Müßiggang) were important in producing sporting success for United Germany. Also, many top-class German athletes who today live in the western part of Germany started their professional sport careers in the East, and can be seen as part of the large-scale exodus of young people from the East to the West since reunification.

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ONC1-0013B inhibits AR activity in vitro. A. ONC1-0013B structure. B. LnCAP cells cultured (10% CSS) for 3 days, then treated with tested compounds in presence of 1nM DHT for 1 day. PSA expression plotted as percentage of vehicle control (DMSO; n=2, mean±SEM). Ki values: ± (ONC1-13B), ± (MDV3100), (ARN-509). Mean±SEM from 5 replicate experiments (except ARN-509). C. LnCAP cells cultured (10% CSS) for 3 days, then treated with tested compounds in presence of 1nM DHT for 5 days. Viable cells plotted as percentage of vehicle control (DMSO; n=2, mean±SEM). IC50 values: 30nM (ONC1-13B), 148nM (MDV3100), 240nM (ARN-509). D. Competitive-binding assay vs AR ligand Fluormone™ (PolarScreen™ Androgen Receptor Competitor Assay). IC50 values: 19nM (DHT), (ONC1-13B), (MDV3100).

All steroid hormones are derived from cholesterol. Contrary to popular belief, “steroid hormone” does not equate with “anabolic hormone”. Not only testosterone but estrogen and progesterone are steroid hormones derived from cholesterol. And most cholesterol in your body is produced by your liver, not from your diet. I know of no controlled studies showing that eating steaks increases testosterone levels. OTOH dietary cholesterol is no longer considered to be the great evil it used to be seen as, so go ahead and eat whole eggs if you like them. The theory that eating red meat makes you more of a man is promoted by people who just happen to like red meat. (There’s nothing wrong with liking red meat, just don’t pretend it has magical powers that it doesn’t have.)

ARN-509 (< 10 μM) inhibits androgen-mediated induction or repression of mRNA expression levels for 13 endogenous genes including PSA and TMPRSS2 in the LNCaP/AR prostate cancer cell line. ARN-509 (< 10 μM) inhibits the proliferative effect of R1881 (30 pM) in the LNCaP/AR prostate cancer cell line. ARN-509 (10 μM) impairs AR nuclear localization and thus reduces the concentration of AR available to bind androgen response elements (ARE) in LNCaP cells expressing AR-EYFP. ARN-509 (10 μM) is able to effectively compete with R1881 (1 nM) and prevent AR from binding to promoter regions. ARN-509 inhibits R1881-induced VP16-AR–mediated transcription with IC50 of μM in Hep-G2 cells expressing a VP16-AR fusion protein and an ARE-driven luciferase reporter. [1]

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All steroid hormones are derived from cholesterol. Contrary to popular belief, “steroid hormone” does not equate with “anabolic hormone”. Not only testosterone but estrogen and progesterone are steroid hormones derived from cholesterol. And most cholesterol in your body is produced by your liver, not from your diet. I know of no controlled studies showing that eating steaks increases testosterone levels. OTOH dietary cholesterol is no longer considered to be the great evil it used to be seen as, so go ahead and eat whole eggs if you like them. The theory that eating red meat makes you more of a man is promoted by people who just happen to like red meat. (There’s nothing wrong with liking red meat, just don’t pretend it has magical powers that it doesn’t have.)

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