Bisquaternary aminosteroid

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Succinylcholine chloride , which is a drug that’s already on the market, is a bischoline ester and a short acting muscle relaxant. Bischoline esters are compounds that can act as a competitive agonist on muscle type nAChRs and have been used in SAR studies. In a Torpedo (α1) 2 β1δγ nAChR model it was demonstrated that the potency of bischoline ester agonists is dependent on the chain length as potency increases with longer chains. Efficacy seems to be independent of chain length since the highest efficacy is seen in bischoline esters with four to seven CH
2 units and is lower for both fewer CH
2 units and more. [21]

Bisquaternary aminosteroid

bisquaternary aminosteroid

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